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Michigan University Launches Extracorporeal CPR Study


ANN ARBOR, Mich. – Even when rapidly treated, less than 10% of sudden cardiac arrest victims survive, according to the American Heart Association. That’s why Michigan Medicine is launching a new study to examine the potential benefit of a life-saving resuscitation strategy for sudden cardiac arrest.

The study, named Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest (EROCA), will examine the potential benefit of quickly transporting out-of-hospital sudden cardiac arrest patients with ongoing CPR and advanced cardiovascular life support (ACLS) to an emergency department capable of performing extracorporeal cardiopulmonary resuscitation (ECPR). It will be performed locally in partnership with Ann Arbor Fire Department and Huron Valley Ambulance.

“Our mission is to provide better emergency care for patients with life-threatening conditions, such as cardiac arrest,” says Robert Neumar, MD, PhD, chair of emergency medicine at Michigan Medicine and co-leader of the study. “This study has the potential to transform the way we treat patients who experience sudden cardiac arrest outside of the hospital and save the lives of those we currently cannot save.”

Currently, the standard practice for treatment of an out-of-hospital cardiac arrest is for emergency medical responders to perform CPR and ACLS at the scene until either the heart is restarted or resuscitation efforts are discontinued due to futility. This practice is supported by the fact that all currently proven therapies can be delivered by EMTs and paramedics in the field. However, promising new investigational strategies have emerged that could save more lives, but are only feasible in the hospital.

One such therapy is ECPR, which uses a machine to take over the function of the heart and lungs until the heart can be restarted. During ECPR, blood from the patient’s veins is passed through an extracorporeal membrane oxygenation device that adds oxygen into the blood and then pumps the blood back into the arteries.

The EROCA study will examine if it is feasible and beneficial to quickly transport out-of-hospital cardiac arrest patients with ongoing CPR and ACLS to an emergency department capable of rapidly initiating ECPR if standard therapy is unsuccessful.

EROCA will enroll adult sudden cardiac arrest patients within the city of Ann Arbor who do not recover after initial attempts of CPR and ACLS.

“Since we don’t yet know which treatment strategy is best, some patients will receive standard care at the scene and some patients will be rapidly transported with CPR and ACLS in progress to the Michigan Medicine Emergency Department where they will be evaluated for ECPR if they remain in cardiac arrest,” Neumar says.

“ECPR is a form of extracorporeal membrane oxygenation, a technique that we have used for decades at the University of Michigan and around the world,” says study co-lead Robert Bartlett, MD, professor emeritus of surgery at Michigan Medicine and pioneer of this life-saving therapy. “The success of ECPR in treating out-of-hospital cardiac arrest will depend on how quickly patients arrive in the emergency department, and the EROCA study is designed to get patients there as quickly as possible.”

The EROCA study is funded by the National Heart, Lung, and Blood Institute and will take place under the U.S. Food and Drug Administration’s Exception From Informed Consent regulations.

For more information about the EROCA study, please visit (link is external).


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